Genetic epidemiology of dengue viruses in phase III trials of the CYD tetravalent dengue vaccine and implications for efficacy.
Identifieur interne : 000B75 ( Main/Exploration ); précédent : 000B74; suivant : 000B76Genetic epidemiology of dengue viruses in phase III trials of the CYD tetravalent dengue vaccine and implications for efficacy.
Auteurs : Maia A. Rabaa [Viêt Nam] ; Yves Girerd-Chambaz [France] ; Kien Duong Thi Hue [Viêt Nam] ; Trung Vu Tuan [Viêt Nam] ; Bridget Wills [Viêt Nam] ; Matthew Bonaparte [États-Unis] ; Diane Van Der Vliet [France] ; Edith Langevin [France] ; Margarita Cortes [Colombie] ; Betzana Zambrano [Uruguay] ; Corinne Dunod [France] ; Anh Wartel-Tram [Singapour] ; Nicholas Jackson [France] ; Cameron P. Simmons [Viêt Nam]Source :
- eLife [ 2050-084X ] ; 2017.
Abstract
This study defined the genetic epidemiology of dengue viruses (DENV) in two pivotal phase III trials of the tetravalent dengue vaccine, CYD-TDV, and thereby enabled virus genotype-specific estimates of vaccine efficacy (VE). Envelope gene sequences (n = 661) from 11 DENV genotypes in 10 endemic countries provided a contemporaneous global snapshot of DENV population genetics and revealed high amino acid identity between the E genes of vaccine strains and wild-type viruses from trial participants, including at epitope sites targeted by virus neutralising human monoclonal antibodies. Post-hoc analysis of all CYD14/15 trial participants revealed a statistically significant genotype-level VE association within DENV-4, where efficacy was lowest against genotype I. In subgroup analysis of trial participants age 9-16 years, VE estimates appeared more balanced within each serotype, suggesting that genotype-level heterogeneity may be limited in older children. Post-licensure surveillance is needed to monitor vaccine performance against the backdrop of DENV sequence diversity and evolution.
DOI: 10.7554/eLife.24196
PubMed: 28871961
Affiliations:
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Development, Sanofi Pasteur, Montevideo, Uruguay.</nlm:affiliation><country xml:lang="fr">Uruguay</country><wicri:regionArea>Research and Development, Sanofi Pasteur, Montevideo</wicri:regionArea><wicri:noRegion>Montevideo</wicri:noRegion></affiliation></author><author><name sortKey="Dunod, Corinne" sort="Dunod, Corinne" uniqKey="Dunod C" first="Corinne" last="Dunod">Corinne Dunod</name><affiliation wicri:level="3"><nlm:affiliation>Research and Development, Sanofi Pasteur, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Research and Development, Sanofi Pasteur, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Wartel Tram, Anh" sort="Wartel Tram, Anh" uniqKey="Wartel Tram A" first="Anh" last="Wartel-Tram">Anh Wartel-Tram</name><affiliation wicri:level="1"><nlm:affiliation>Medical Affairs and Public Policy Asia AP, Sanofi Pasteur, Singapore, Singapore.</nlm:affiliation><country xml:lang="fr">Singapour</country><wicri:regionArea>Medical Affairs and Public Policy Asia AP, Sanofi Pasteur, Singapore</wicri:regionArea><wicri:noRegion>Singapore</wicri:noRegion></affiliation></author><author><name sortKey="Jackson, Nicholas" sort="Jackson, Nicholas" uniqKey="Jackson N" first="Nicholas" last="Jackson">Nicholas Jackson</name><affiliation wicri:level="3"><nlm:affiliation>Research and Development, Sanofi Pasteur, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Research and Development, Sanofi Pasteur, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P" last="Simmons">Cameron P. Simmons</name><affiliation wicri:level="1"><nlm:affiliation>Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.</nlm:affiliation><country xml:lang="fr">Viêt Nam</country><wicri:regionArea>Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City</wicri:regionArea><wicri:noRegion>Ho Chi Minh City</wicri:noRegion></affiliation></author></analytic><series><title level="j">eLife</title><idno type="eISSN">2050-084X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study defined the genetic epidemiology of dengue viruses (DENV) in two pivotal phase III trials of the tetravalent dengue vaccine, CYD-TDV, and thereby enabled virus genotype-specific estimates of vaccine efficacy (VE). Envelope gene sequences (n = 661) from 11 DENV genotypes in 10 endemic countries provided a contemporaneous global snapshot of DENV population genetics and revealed high amino acid identity between the E genes of vaccine strains and wild-type viruses from trial participants, including at epitope sites targeted by virus neutralising human monoclonal antibodies. Post-hoc analysis of all CYD14/15 trial participants revealed a statistically significant genotype-level VE association within DENV-4, where efficacy was lowest against genotype I. In subgroup analysis of trial participants age 9-16 years, VE estimates appeared more balanced within each serotype, suggesting that genotype-level heterogeneity may be limited in older children. Post-licensure surveillance is needed to monitor vaccine performance against the backdrop of DENV sequence diversity and evolution.</div></front></TEI><affiliations><list><country><li>Colombie</li><li>France</li><li>Singapour</li><li>Uruguay</li><li>Viêt Nam</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li></settlement></list><tree><country name="Viêt Nam"><noRegion><name sortKey="Rabaa, Maia A" sort="Rabaa, Maia A" uniqKey="Rabaa M" first="Maia A" last="Rabaa">Maia A. Rabaa</name></noRegion><name sortKey="Duong Thi Hue, Kien" sort="Duong Thi Hue, Kien" uniqKey="Duong Thi Hue K" first="Kien" last="Duong Thi Hue">Kien Duong Thi Hue</name><name sortKey="Simmons, Cameron P" sort="Simmons, Cameron P" uniqKey="Simmons C" first="Cameron P" last="Simmons">Cameron P. Simmons</name><name sortKey="Vu Tuan, Trung" sort="Vu Tuan, Trung" uniqKey="Vu Tuan T" first="Trung" last="Vu Tuan">Trung Vu Tuan</name><name sortKey="Wills, Bridget" sort="Wills, Bridget" uniqKey="Wills B" first="Bridget" last="Wills">Bridget Wills</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Girerd Chambaz, Yves" sort="Girerd Chambaz, Yves" uniqKey="Girerd Chambaz Y" first="Yves" last="Girerd-Chambaz">Yves Girerd-Chambaz</name></region><name sortKey="Dunod, Corinne" sort="Dunod, Corinne" uniqKey="Dunod C" first="Corinne" last="Dunod">Corinne Dunod</name><name sortKey="Jackson, Nicholas" sort="Jackson, Nicholas" uniqKey="Jackson N" first="Nicholas" last="Jackson">Nicholas Jackson</name><name sortKey="Langevin, Edith" sort="Langevin, Edith" uniqKey="Langevin E" first="Edith" last="Langevin">Edith Langevin</name><name sortKey="Van Der Vliet, Diane" sort="Van Der Vliet, Diane" uniqKey="Van Der Vliet D" first="Diane" last="Van Der Vliet">Diane Van Der Vliet</name></country><country name="États-Unis"><noRegion><name sortKey="Bonaparte, Matthew" sort="Bonaparte, Matthew" uniqKey="Bonaparte M" first="Matthew" last="Bonaparte">Matthew Bonaparte</name></noRegion></country><country name="Colombie"><noRegion><name sortKey="Cortes, Margarita" sort="Cortes, Margarita" uniqKey="Cortes M" first="Margarita" last="Cortes">Margarita Cortes</name></noRegion></country><country name="Uruguay"><noRegion><name sortKey="Zambrano, Betzana" sort="Zambrano, Betzana" uniqKey="Zambrano B" first="Betzana" last="Zambrano">Betzana Zambrano</name></noRegion></country><country name="Singapour"><noRegion><name sortKey="Wartel Tram, Anh" sort="Wartel Tram, Anh" uniqKey="Wartel Tram A" first="Anh" last="Wartel-Tram">Anh Wartel-Tram</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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